Interdigitated Evaporation Chip for Efficient Solvent Exchange in Microchannels
نویسندگان
چکیده
Evaporative solvent exchange, a critical process in multi-step batch synthesis of positron emission tomography (PET) tracers, can readily be accomplished in poly(dimethylsiloxane) (PDMS) chips due to its high vapor permeability. Early proof-of-concept chips, however, suffered reliability issues, such as clogged channels and stuck valves. We demonstrated in previous work that by controlling the evaporation in such a way as to fragment the partially-evaporated liquid leads to random distribution of solutes throughout the channel and avoids clogging. The chip presented here results in improved uniformity of solute residue by using a valve structure to subdivide the liquid sample before evaporation.
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